However, the vernacular nomenclature incited some controversy and Crossley and co-workers suggested a composite phenomenon using polytope formalism which is the fundamental of akamptisomerism classification 5. More recently, Baran and co-workers accomplished the reported total synthesis of the peptidic indole alkaloid tryptorubin A and defined non-canonical atropisomers, a family of shape-defined molecules that are distinguished by bridge below/bridge above arrangements (Fig. The Yudin group reported an unusual tunable atropisomeric peptidyl macrocycle which is made possible by controlling the conformational interconversion 3. investigated the diastereomeric norbornapeptides as potential drug scaffolds which showed bridge-up/down orientations according to the NMR solution structure (Fig. describe the homeomorphic isomerism of macrobicyclic peptidic compounds which involved a passage of the bridge chain through the macrolactam (Fig. There exist various literature reports: Wareham et al. The chemical synthesis of constrained peptide macrocycles of natural origin or of designed artificial peptides sometimes leads to the occurrence of isomers, which have been designated with various terms.
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